
Monthly topical protection against key feline parasites
Product Description
NexGard COMBO is a prescription topical solution for cats weighing 5.6–16.5 lbs. It provides broad-spectrum parasite protection by killing adult fleas and controlling certain ticks for one month, preventing heartworm disease, and treating and controlling common intestinal worms. The dose is applied to the skin on the neck using a single-use applicator once monthly, as directed.
Benefits
- Broad Coverage: Kills fleas, controls ticks, prevents heartworm, treats intestinal worms.
- Once-Monthly Dosing: Applies monthly for consistent parasite protection coverage.
- Topical Convenience: No tablets needed; simple spot-on administration.
- Weight-Specific Dose: Designed for cats in the 5.6–16.5 lb range.
- Multi-Ingredient Action: Combines three actives for internal and external control.

Variants
- NexGard COMBO Topical for Cats 1.8-5.5 lbs
- NexGard COMBO Topical for Cats 5.6-16.5 lbs
Ingredients
Active Ingredients
Esafoxolaner, Eprinomectin, Praziquantel
How to Use
Directions for Use
- Dosing Chart:6–16.5 lb. cats use 0.9 mL applicator; apply entire contents.
- Monthly Schedule: Apply topically once a month, as directed.
- Application Site: Apply on the neck between the skull base and the shoulder blades.
- Skin Placement: Part hair to skin and apply in one spot only.
- Hand Hygiene: Wash hands with soap and water after use.
Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.
Additional Information
Precautions
- Topical Only: Do not administer orally; ingestion may cause excessive salivation.
- Human Contact: Avoid contact with the application site for 4 hours or until dry.
- Neurologic Caution: Use cautiously in cats with seizures or neurologic disorders.
- Age/weight Limits: Not tested in kittens under 8 weeks or under 1.8 lbs.
- Breeding Status: Safety not fully evaluated in breeding, pregnancy, or lactating cats.
Shipping & Returns
We offer ground, express, priority, and international delivery; see our shipping policy for details.
For return instructions or product concerns, please refer to our detailed refund policy.
Prescription items are NON-RETURNABLE and NON-REFUNDABLE.
Frequently Asked Questions
Q1: What parasites does NexGard COMBO protect cats against?
Ans: NexGard COMBO is indicated to prevent heartworm disease and to treat and control roundworms, hookworms, and tapeworms. NexGard COMBO also kills adult fleas and is indicated for the treatment and prevention of flea infestations, as well as specific tick infestations, for a period of one month.
Q2: How often is NexGard COMBO applied for ongoing protection?
Ans: NexGard COMBO is applied topically once a month. Monthly dosing provides continuous protection against labeled parasites. It can be used year-round, based on regional parasite risk and veterinary guidance, particularly for heartworm prevention, where consistent monthly dosing is crucial.
Q3: Where exactly should the topical dose be applied to a cat?
Ans: Apply the full contents to the skin on the midline of the neck, between the base of the skull and the shoulder blades. Part the hair until skin is visible, then apply it in one spot on an area the cat cannot lick.
Q4: What is the correct dose for cats weighing 5.6–16.5 lbs?
Ans: For cats weighing 5.6–16.5 lbs, use the 0.9 mL unit applicator and apply the entire contents topically in a single spot. Using the correct weight-range applicator helps ensure the intended minimum dosing of all active ingredients.
Q5: Can cats lick the application area after NexGard COMBO is applied?
Ans: Cats should not be able to lick the application site. Apply to the neck area where licking is minimized and prevent contact between pets until the site is dry. If licking occurs, oral exposure can lead to excessive salivation.
Q6: Are there warnings about neurologic side effects with NexGard COMBO?
Ans: Esafoxolaner is an isoxazoline, a class associated with neurologic adverse reactions such as tremors, ataxia, and seizures. Seizures have been reported even without prior history, so use caution in cats with seizure or neurologic disorders.
Q7: Is NexGard COMBO approved for kittens?
Ans: NexGard COMBO is indicated for cats and kittens 8 weeks of age and older and weighing 1.8 lbs or greater. The product has not been tested in kittens younger than 8 weeks or weighing less than 1.8 lbs.
Q8: What should people do after applying the topical solution?
Ans: Avoid direct contact with the application site for 4 hours or until the area is visibly dry. Wash your hands with soap and water after application. The product may cause mild to moderate eye irritation, so avoid eye contact.
Q9: Does NexGard COMBO require a prescription?
Ans: Yes. NexGard COMBO is a prescription animal drug and should be used by or on the order of a licensed veterinarian. Veterinary direction helps ensure the correct weight-range product selection and appropriate parasite prevention strategy for the cat.
Q10: What should happen if a monthly dose is missed?
Ans: If a dose is missed and the 30-day interval between doses is exceeded, apply NexGard COMBO immediately and resume the monthly dosing schedule. Consistent monthly dosing is especially important when using NexGard COMBO for heartworm prevention.
This Shipping Policy explains how orders are processed, shipped, tracked, and delivered.
1. Shipping Origin and Fulfillment
Orders are dispatched from our U.S.-based fulfillment center. We deliver to eligible addresses within the United States and to eligible international destinations shown at checkout.
If a destination, shipping service, or product is not eligible for delivery, checkout will not offer that shipping option.
2. Order Processing Time
Orders are generally processed within 1–5 business days before shipment. Processing time is separate from carrier transit time.
Our order cut-off time is 6:00 PM Pacific Time (PT). Orders placed after the cut-off time, on weekends, or on applicable holidays begin processing on the next business day.
Processing may include order verification and preparation for shipment.
3. U.S. Shipping Methods, Costs, and Transit Times
For eligible U.S. addresses, our current shipping options are:
- Priority Shipping: $5.99 — estimated carrier transit time of 1–2 business days after shipment.
- Standard Shipping: $2.99 — estimated carrier transit time of 3–6 business days after shipment.
- Free Shipping: $0 — estimated carrier transit time of 5–8 business days after shipment.
Total estimated delivery time includes both the 1–5 business day processing period and the applicable carrier transit time. The shipping service, cost, and delivery estimate available for your order are shown at checkout before payment.
4. International Shipping
We ship to eligible international destinations. Available international shipping services, shipping charges, and estimated delivery times vary by destination and are displayed at checkout.
For eligible international orders, applicable import duties and taxes are calculated and collected at checkout where required. When these charges apply, the order is shipped on a duties-and-taxes-paid basis so that the same import charges should not be collected again at delivery.
International delivery estimates may be affected by carrier operations, customs processing, local holidays, weather, or other events outside normal transit conditions.
5. Tracking
When tracking is available, you will receive shipment confirmation with tracking information after the order has shipped. Please allow up to 48 hours for tracking information to become active after the carrier receives the shipment.
6. Address Accuracy and Changes
Please review your shipping address carefully before submitting an order. If you notice an address error, contact us as soon as possible. We will try to help before shipment, but an address change cannot be guaranteed once fulfillment or carrier processing has begun.
Additional carrier or re-delivery charges resulting from an incorrect or incomplete address may be the customer's responsibility where permitted by law.
7. Delayed or Lost Shipments
If your shipment has not arrived within the estimated delivery timeframe, please contact us. We will review the tracking information, work with the carrier when necessary, and assist with an appropriate resolution based on the circumstances.
Delivery estimates are not guarantees and may be affected by carrier delays, weather, public holidays, customs processing, or other transportation disruptions.
8. Damaged, Defective, or Incorrect Deliveries
If an item arrives damaged, defective, or incorrect, contact us within 7 calendar days after confirmed delivery. Please include your order number and clear photos of the item, packaging, and shipping label when relevant.
Approved cases are handled under our Return & Refund Policy, including return-shipping assistance when the issue is our responsibility.
9. Policy Updates
We may update this Shipping Policy when our shipping services or operating requirements change. The current version will be posted on this page.
10. Contact Us
If you have questions about shipping or an order in transit, please use our Contact page or the current contact information displayed in the website footer.
This Return & Refund Policy explains when a return is eligible, how to send an item back, who pays return shipping, and how approved refunds are processed.
1. Return Window
You may request an eligible return within 30 days after confirmed delivery. Return requests submitted after the 30-day period are not accepted unless applicable law requires otherwise.
2. Return Eligibility
To qualify for a standard return, the item must generally be:
- Unused, unwashed, and in its original condition.
- Returned with the original packaging, tags, accessories, manuals, and other included components, when applicable.
- Not specifically identified as final sale or non-returnable before purchase.
Products that show use, alteration, avoidable damage, missing components, or other conditions outside the eligibility requirements may be ineligible for a refund.
3. Product-Specific Non-Returnable Items
Some products may be non-returnable for hygiene, safety, customization, final-sale, or other product-specific reasons. Any such restriction will be disclosed on the product page or before purchase when applicable.
4. No Direct Exchanges
We do not provide direct exchange service. If you want a different item, size, color, model, or version, return the eligible original item under this Policy and place a new order separately.
5. How to Start a Return
Returns are handled by mail. Before sending an item back, contact our customer support team through the Contact page or the current contact information displayed in the website footer. Please provide:
- Your order number.
- The item or items you want to return.
- The reason for the return.
Returns sent without required return authorization may be delayed or refused.
6. Prepaid Return Label and Return Shipping Cost
For eligible mail returns, a prepaid return label is included in the package.
For a standard return made for customer-choice reasons, the actual carrier postage charged for use of the prepaid return label will be deducted from the approved refund. We do not charge a separate restocking fee.
If the return is required because the item arrived damaged, defective, or incorrect and the claim is approved, we cover the return-label cost.
If you choose not to use the provided label when an alternative return method is authorized, use a trackable shipping service and keep your shipping receipt until the return is completed.
7. Original Shipping Charges
Original outbound shipping charges are non-refundable for standard customer-choice returns, except where required by law. If the return results from an approved damaged, defective, or incorrect item, applicable shipping charges will be handled as part of the resolution.
8. Refund Review and Processing
After the returned item is received, we inspect it and notify you whether the refund is approved.
If approved, the refund is issued to the original payment method. We generally process an approved refund within 1–3 business days. After the refund is issued, your bank or card provider may require an additional 5–10 business days to post the funds to your account.
9. Damaged, Defective, or Incorrect Items
If an item arrives damaged, defective, or incorrect, contact us within 7 calendar days after confirmed delivery. Include your order number and clear photos of the item, packaging, and shipping label when relevant.
After review, we will provide an appropriate resolution. When a return is required for an approved claim, we cover the return shipping cost.
10. Refused or Undeliverable Shipments
If a shipment is refused or returned because of incorrect or incomplete customer-provided shipping information, actual carrier return, re-delivery, or related shipping charges may be deducted from an otherwise eligible refund where permitted by law.
11. Policy Updates
We may update this Return & Refund Policy when our return procedures or legal requirements change. The current version will be posted on this page.
12. Contact Us
If you need help with a return or refund, please use our Contact page or the current contact information displayed in the website footer.
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